10.30 Jo Colston (NIMR, London) Welcome address from Chairman of the Acid Fast Club
10.35 John Stephenson (Wellcome Trust) The involvement of the Wellcome Trust in bacterial genome sequencing
10.50 Bart Barrell (Sanger Centre) Sequencing of the Mycobacterium tuberculosis genome
11.30 Stewart Cole (Inst. Pasteur, Paris) Analysis of mycobacterial genomes
12.10 Richard Moxon (IMM, John Radcliffe Hospital, Oxford) Use of whole genome sequence of Haemophilus influenzae to investigate the biology of LPS
12.50 Lunch; Tours of the Sanger Centre
2.00 Ken Duncan (Glaxo Wellcome, Stevenage) From genomics to targets and vaccines
2.40 Harry Thangaraj (RPMS, Hammersmith) Comparative genome sequencing the pstS operon of Mycobacterium intracellulare, M.leprae and M.tuberculosis
3.00 R Bellamy et al. (WellcomeTrust for Human Genomics, Oxford ; MRC, Gambia) A genome-wide search for genes involved in host susceptibility to human tuberculosis
3.20 Paul R Wheeler (LSHTM,London) Glycosyltransferases in mycobacteria: polyprenol-phosphomannose biosynthesis as an entry point
3.40 Johannes Hegemann (Justus-Liebig-Univ., Giessen, Germany) Use of yeast genome information
4.20 Tea; Business Meeting
4.50 John Magee & Mike Goodfellow (PHLS, Newcastle upon Tyne) Mycobacterial systematics: strengths and weaknesses of 16S rRNA sequencing
5.05 R Senaratne et al. (NIMR, London) A porin-like gene of M. tuberculosis
5.20 David OÕConnor (Southampton Univ.) Proteome analysis of microbial pathogens: applications and challenges
6.00 Sherry and wine reception All welcome
7.00 Dinner Need to book in advance, by July 1st.
9.30 INTRODUCTION
9.40 WORKSHOP 1: BIOINFORMATICS
Chair: Neil Stoker (LSHTM, London)
Lead Speaker: To be arranged
Speakers:
Marian Blokpoel (Imperial College, London; introduced by Koen
De Smet) Antibiotic resistance: efflux genes in M. tuberculosis
Steve Michell (CVL, Weybridge; introduced by Glyn Hewinson) Identification of MPT53, a novel secreted antigen of M. tuberculosis
Mark Pallen (Imperial College, London; introduced by Neil Stoker) Finding families for orphan genes
R Delahay (Imperial College, London; introduced by Douglas Young) Identification of potentially glycosylated mycobacterial lipoproteins
To be arranged The WHO synthetic peptide initiative for new leprosy skin test reagents- the use of bioinformatics
Open discussion and short informal presentations
12.00 Lunch
1.00 WORKSHOP 2: GENE FUNCTION
Chair: Jeremy Dale (University of Surrey, Guildford)
Lead Speaker: Douglas Young (Imperial College, London)
Speakers:
G Bachrach (NIMR, London; introduced by MJ Colston) A novel
approach to the trapping of activated promoters; promoter self-amplification.
A Coates (St Georges, London) Upregulation of the M. tuberculosis haemoglobin-like hmp gene mRNA during entry into dormancy.
PD Butcher (St Georges, London) Proteome maps from M. tuberculosis during infection.
Open discussion and short informal presentations
2.30 Tea
2.50 - 3.40 Plenary session: Report back and discussion Panel:
Jo Colston (chair), John Stephenson, Neil Stoker, Jeremy Dale, Douglas
Young
Summary: Jo Colston